Most Recent Articles Martyny JW,Van Dyke MV,Arbuckle S,Towle M,Rose CS Diacetyl Exposures in the Flavor Manufacturing Industry. J Occup Environ Hyg, 2008 Nov Sahakian N, Kullman G, Lynch D, Kreiss K. Asthma arising in flavoring-exposed food production workers. Int J Occup Med Environ Health 2008,21,2,173-7 Articles published in 2008 Galbraith,D.; Weill,D. Diacetyl and bronchiolitis obliterans. Am.J.Respir.Crit.Care Med., 2008 Galbraith,D.; Weill,D. Popcorn lung and bronchiolitis obliterans: a critical appraisal.Int.Arch.Occup.Environ.Health, 2008 Hubbs,A.F.; Goldsmith,W.T.; Kashon,M.L.; Frazer,D.; Mercer,R.R.;Battelli,L.A.; Kullman,G.J.; Schwegler-Berry,D.; Friend,S.; Castranova,V. Respiratory toxicologic pathology of inhaled diacetyl in sprague-dawley rats. Toxicol.Pathol., 2008, 36, 2, 330-344 Whittaker,P.; Clarke,J.J.; San,R.H.; Begley,T.H.; Dunkel,V.C. Evaluation of the butter flavoring chemical diacetyl and a fluorochemical paper additive for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells. Food Chem.Toxicol., 2008 Modi,P.; Yadava,V.; Sreedhar,R.; Khasawaneh,F.; Balk,R.A. A case of flavor-induced lung disease.South.Med.J., 2008, 101, 5, 541-542 Horton,M.R. Respiratory CSI: diagnosing occupationally related lung disease.South.Med.J., 2008, 101, 5, 466 Kanwal,R. Bronchiolitis obliterans in workers exposed to flavoring chemicals. Curr.Opin.Pulm.Med., 2008, 14, 2, 141-146 Morgan,D.L.;Flake,G.P.; Kirby,P.J.; Palmer,S.M. Respiratory toxicity of diacetyl in C57BL/6 mice. Toxicol.Sci., 2008, 103, 1,169-180 Articles published before 2008 Akpinar-Elci, M., Travis, W. D., Lynch, D. A., & Kreiss, K. (2004). Bronchiolitis obliterans syndrome in popcorn production plant workers. The European Respiratory Journal : Official Journal of the European Society for Clinical Respiratory Physiology, 24(2), 298-302. BASF. (1993). Study on inhalation toxicity of diacetyl FCC as a vapor in rats: 4 hour exposure. No. 1310247/927010 Boylstein, R., Piacitelli, C., Grote, A., Kanwal, R., Kullman, G., & Kreiss, K. (2006). Diacetyl emissions and airborne dust from butter flavorings used in microwave popcorn production. Journal of Occupational and Environmental Hygiene, 3(10), 530-535. Centers for Disease Control and Prevention (CDC). (2002). Fixed obstructive lung disease in workers at a microwave popcorn factory--missouri, 2000-2002. MMWR.Morbidity and Mortality Weekly Report, 51(16), 345-347. Centers for Disease Control and Prevention (CDC). (2007). Fixed obstructive lung disease among workers in the flavor-manufacturing industry--california, 2004-2007. MMWR.Morbidity and Mortality Weekly Report, 56(16), 389-393. Egilman, D., Mailloux, C., & Valentin, C. (2007). Popcorn-worker lung caused by corporate and regulatory negligence: An avoidable tragedy. International Journal of Occupational and Environmental Health, 13(1), 85-98. Fedan, J. S., Dowdy, J. A., Fedan, K. B., & Hubbs, A. F. (2006). Popcorn worker's lung: In vitro exposure to diacetyl, an ingredient in microwave popcorn butter flavoring, increases reactivity to methacholine. Toxicology and Applied Pharmacology, 215(1), 17-22. Harber, P., Saechao, K., & Boomus, C. (2006). Diacetyl-induced lung disease. Toxicological Reviews, 25(4), 261-272. Hubbs, A. F., Battelli, L. A., Goldsmith, W. T., Porter, D. W., Frazer, D., Friend, S., et al. (2002). Necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring. Toxicology and Applied Pharmacology, 185(2), 128-135. Kanwal, R., Kullman, G., Piacitelli, C., Boylstein, R., Sahakian, N., Martin, S., et al. (2006). Evaluation of flavorings-related lung disease risk at six microwave popcorn plants. Journal of Occupational and Environmental Medicine / American College of Occupational and Environmental Medicine, 48(2), 149-157. Kreiss, K. (2007). Flavoring-related bronchiolitis obliterans. Current Opinion in Allergy and Clinical Immunology, 7(2), 162-167. Kreiss, K. (2007). Occupational bronchiolitis obliterans masquerading as COPD. American Journal of Respiratory and Critical Care Medicine, 176(5), 427-429. Kreiss, K., Gomaa, A., Kullman, G., Fedan, K., Simoes, E. J., & Enright, P. L. (2002). Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. The New England Journal of Medicine, 347(5), 330-338. Kullman, G., Boylstein, R., Jones, W., Piacitelli, C., Pendergrass, S., & Kreiss, K. (2005). Characterization of respiratory exposures at a microwave popcorn plant with cases of bronchiolitis obliterans. Journal of Occupational and Environmental Hygiene, 2(3), 169-178. Moss, M. H. (2007). Potential exposures to the chemical, diacetyl, in connecticut workplaces. Connecticut Medicine, 71(7), 439. National Toxicology Program (2007). Chemical information review document for artificial butter flavoring. No. N01-ES-35515 Parmet, A. J. (2002). Bronchiolitis in popcorn-factory workers. The New England Journal of Medicine, 347(24), 1980-2; author reply 1980-2; discussion 1980-2. Parmet, A. J., & Von Essen, S. (2002). Rapidly progressive, fixed airway obstructive disease in popcorn workers: A new occupational pulmonary illness? Journal of Occupational and Environmental Medicine / American College of Occupational and Environmental Medicine, 44(3), 216-218. Pendergrass, S. M. (2004). Method development for the determination of diacetyl and acetoin at a microwave popcorn plant. Environmental Science & Technology, 38(3), 858-861. Rosati, J. A., Krebs, K. A., & Liu, X. (2007). Emissions from cooking microwave popcorn. Critical Reviews in Food Science and Nutrition, 47(8), 701-709. Schachter, E. N. (2002). Popcorn worker's lung. The New England Journal of Medicine, 347(5), 360-361. van Rooy, F. G., Rooyackers, J. M., Prokop, M., Houba, R., Smit, L. A., & Heederik, D. J. (2007). Bronchiolitis obliterans syndrome in chemical workers producing diacetyl for food flavorings. American Journal of Respiratory and Critical Care Medicine, 176(5), 498-504.